Spegra Tablet is a combination of three medicines: Dolutegravir, Emtricitabine and Tenofovir Alafenamide. It is an anti-HIV medication and works by preventing the action of reverse transcriptase enzyme. This enzyme is responsible for production of HIV.Spegra Tablet is a combination of three medicines: Dolutegravir, Emtricitabine and Tenofovir Alafenamide. It is an anti-HIV medication and works by preventing the action of reverse transcriptase enzyme. This enzyme is responsible for production of HIV.