The active substance is estradiol 1 mg or 2 mg (as estradiol hemihydrate).
Excipients/Inactive Ingredients: Tab 1 mg: lactose monohydrate, maize starch, hydroxypropylcellulose, talc and magnesium stearate.
The film-coating contains: hypromellose, talc, titanium dioxide (E171), propylene glycol and red iron oxide (E172).
Tab 2 mg: lactose monohydrate, maize starch, hydroxypropylcellulose, talc and magnesium stearate. Film-coating: Hypromellose, talc, titanium dioxide (E171), macrogol 400 and indigo carmine (E132).

Indications/Uses

Estrofem is a Hormone Replacement Therapy (HRT). It contains the female hormone estradiol.
Estrofem is used in postmenopausal women, particularly in women who have had their womb removed (have had a hysterectomy) and therefore do not require combined oestrogen/progestagen therapy.
Estrofem is used for: Relief of symptoms occurring after menopause: During the menopause, the amount of oestrogen produced by a woman’s body drops. This can cause symptoms such as hot face, neck and chest (‘hot flushes’). Estrofem alleviates these symptoms after menopause. Estrofem should only be prescribed if the symptoms seriously hinder the patient’s daily life.
Prevention of osteoporosis: (thinning of the bones), if the patient is at high risk of future fracture and if unable to take other medications for this purpose.
There is only limited experience of treating women older than 65 years.

Dosage/Direction for Use

Always take Estrofem exactly as told by the doctor. Check with the doctor or pharmacist if unsure.
If the womb has been removed or if the patient has no vaginal bleeding and is not taking other hormone therapy products, treatment can be started on any convenient day.
Take one tablet every day, at about the same time each day. After finishing all the 28 tablets in the pack, start a new pack continuing the treatment without interruption.
For instructions on the use of the calendar pack, see Cautions for Usage.
The doctor will aim to prescribe the lowest dose to treat the symptoms for as short as necessary. Talk to the doctor if the patient thinks this dose is too strong or not strong enough.
If the patient has had the womb removed, the doctor will not prescribe a progestagen (another female hormone) in addition unless the patient has had a condition called endometriosis (deposition of uterine tissue outside the womb).
If the patient has taken other HRT products until now, ask the doctor or pharmacist when the patient should start taking Estrofem.
If the patient gets breakthrough bleeding or spotting, it is usually nothing to worry about, especially during the first few months of taking HRT (see Precautions).
If the patient forgets to take Estrofem: If the patient forgets to take the tablet at the usual time, take it within the next 12 hours. If more than 12 hours have gone by, skip the missed dose and start again as normal the next day. Do not take a double dose to make up for a forgotten tablet. Forgetting a dose may increase the likelihood of breakthrough bleeding and spotting, if the patient still has her womb.
If the patient stops taking Estrofem: If the patient wants to stop taking Estrofem, talk to the doctor first. The doctor will explain the effects of stopping treatment and discuss other possibilities with the patient.
If patient has any further questions on the use of this product, ask the doctor or pharmacist.
If the patient